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Autoimmune Disease Linked to Estrogen Deficiency

Estrogen may have a new purpose in treating or preventing certain types of autoimmune disease, according to a study. Autoimmune diseases, like Sjögren’s syndrome, are much more prevalent in women than men. This suggests that estrogen probably plays an important role in the disease; however, no definitive link has yet been found. Researchers from the Karolinska Institute and colleagues report that estrogen-deficient mice develop an autoimmune disease that resembles Sjögren’s syndrome. To investigate the possible role of estrogen in such diseases, the researchers examined genetically engineered mice that lacked aromatase, an enzyme that helps make estrogen. The ARKO mice showed increased production of certain immune cells, increased numbers of white blood cells in the salivary glands, renal damage, and had… Read more..