[4/23/15] What role does our genetic makeup play in autoimmune diseases – diseases like lupus and multiple sclerosis wherein the body’s own immune system turns on itself? That question has plagued researchers for decades. However, a new gene mutation has been discovered that could help scientists map an autoimmune disease in the body and find out how the immune system is inappropriately triggered to attack the body. Researchers in a new study at the University of Edinburgh have honed in on five of 89 independent variations in human genetics that are believed to be responsible for autoimmune conditions, from celiac disease and multiple sclerosis to rheumatoid arthritis and asthma. Understanding how these mechanisms work could help scientists to develop new treatments…. Read more..
Posts Categorized: News & Information
[4/8/15] Researchers have revealed the presence of two antibodies in a subgroup of children experiencing their first episode of psychosis, affirming a longstanding recognition that autoimmune disorders play a significant role in psychiatric illness. Researchers from the Kids Research Institute at The Children’s Hospital at Westmead and the University of Sydney detected antibodies to the dopamine-2 receptor (D2R) or the glutamatergic N-methyl-D-aspartate receptor (NMDAR) among eight out of 43 children experiencing their first episode of psychosis, but no such antibodies in healthy children. Both receptors are key neural signalling proteins previously implicated in psychosis. Dopamine is a chemical messenger aiding the transmission of signals in the brain and other areas of the body. Abnormalities in dopaminergic neurotransmission play a key… Read more..
[4/4/15] A team of co-researchers from the Korea Research Institute of Bioscience and Biotechnology and Harvard Medical School believes that regulatory T cells formed right after birth may be the key to supressing autoimmune disorders. Regulatory T cells in a newborn baby are much more effective in tackling autoimmunity or metabolic disease. This new discovery could be the key in developing treatment for cell disorders. The researchers confirmed that newborn T cells are much more effective than T cells produced in adulthood. Regulatory T cells are suppressive cells that are essential to modulate the immune system. A deficiency of these cells can lead to the development of autoimmune disorders where the body attacks its own cells and tissues, for example… Read more..
[3/24/15] This week the Scripps Research Institute (TSRI) unveiled what could one day represent not just a symptom-abating therapy, but a genuine cure for type 1 diabetes. According to a study published in the March issue of Endocrinology, TSRI researchers tested an experimental compound known as SR1001 in non-obese but diabetic animal models and observed that it completely stopped type 1 diabetes from developing. Specifically, researchers noted that SR1001 completely eliminated the incidence of diabetes, it maintained insulin levels, and it reduced inflammation associated with insulin-producing cells, which is a common occurrence in type 1 diabetic patients. By targeting a specific pair of receptors with SR1001, researchers were able to suppress a targeted immune response that creates Th17 cells,… Read more..
[3/18/15] The microbiome is big news in health this year. Fortune Magazine has declared 2015 The Year of the Microbiome, and there is significant research going on to fully understand its complex relationship to health and disease, notably the multimillion-dollar five-year Human Microbiome Project. But what is is? And why is getting so much attention? Did you know you have ten times more bacteria in your gut than human cells? Millions are being spent on research to uncover its crucial role in health and disease. Scientists have become very interested about what’s in our stomachs.We have more bacteria in our body than we do human cells, up to ten times more. Most of them are in our intestines; we each have literally trillions of bacteria… Read more..
[3/4/15] A new genomic study reveals a link between powerful gene regulatory elements and autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Autoimmune disorders result when the body’s immune system mistakenly attacks and destroys healthy body tissue; different tissues are affected in different diseases; about 80 have been recognised. The causes of these diseases are not well understood, but scientists believe there is a genetic component as they often run in families. It can be challenging to identify specific genetic risk factors for autoimmune disease, since in most cases they are the result of a complex mix of genetic and environmental factors. However, it is useful; Stephen Katz, Director of the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)… Read more..
[2/10/15] One of the greatest risk factors for autoimmunity among women of childbearing age may be associated with exposure to mercury such as through seafood, a new University of Michigan study says. The findings, which appear in Environmental Health Perspectives, found that mercury – even at low levels generally considered safe – was associated with autoimmunity. Autoimmune disorders, which cause the body’s immune system to attack healthy cells by mistake, affects nearly 50 million Americans and predominately women. “We don’t have a very good sense of why people develop autoimmune disorders,” says lead author Emily Somers, Ph.D., Sc.M, an associate professor in the departments of Internal Medicine in the division of Rheumatology, Environmental Health Sciences, and Obstetrics & Gynecology at… Read more..
[1/22/15] A new drug to treat adults with moderate-to-severe plaque psoriasis was approved Wednesday by the U.S. Food and Drug Administration. People with plaque psoriasis, the most common form of the autoimmune skin disease, develop thick, red skin with flaky, silver-white patches called scales. In autoimmune diseases, the body’s immune system attacks healthy tissue by mistake. The new drug, Cosentyx (secukinumab), is injected under the skin. The drug blocks a protein involved in the inflammatory response that causes plaque psoriasis, according to the FDA. “Plaque psoriasis can cause significant skin irritation and discomfort for patients, so it is important to have a variety of treatment options available to patients,” Dr. Amy Egan, deputy director of the Office of Drug Evaluation… Read more..
[1/21/15] St. Jude Children’s Research Hospital scientists in Memphis, TN, have discovered that a protein widely known for suppressing tumour formation also helps prevent autoimmune diseases and other problems by putting the brakes on the immune response. The research was published recently online ahead of print in the scientific journal Nature Immunology. Researchers showed that the tumour suppressor protein PTEN is essential for proper functioning of regulatory T cells. This small population of white blood cells helps to maintain immune system balance by suppressing specialized T cells called helper T cells that fuel distinct parts of the immune response. The helper T cells investigated in this study included type 1 T helper (Th1) and follicular T helper (Tfh) cells. The interplay… Read more..
[1/14/15] Human gut bacteria that feast on the yeast contained in fermented foods like bread and beer provides clues to new treatments for people suffering from bowel diseases. University of Melbourne researchers collaborating with scientists from the UK, USA Canada and Belgium have unravelled the process healthy gut bacteria use to degrade complex carbohydrates in the wall of yeast cells contained in fermented foods. Publishing their findings in Nature, the international research team say the discovery of this process could accelerate the development of prebiotic medicines to help people suffering from bowel problems and autoimmune diseases. Coauthor Professor Spencer Williams, School of Chemistry School of Chemistry, University of Melbourne and Bio 21 explains: The common gut bacteria called Bacteroides thetaiotaomicron… Read more..